ROLE OF DOMESTIC AMINO ACID BLOOD SUBSTITUTE ON METABOLIC DISORDERS AND ENDOGENOUS INTOXICATION IN EXPERIMENTAL TOXIC HEPATITIS

Abstract

The development of effective agents to correct metabolic balance in critical illness is critical for the successful treatment of serious diseases. Critical conditions such as trauma, poisoning, burns, sepsis and surgery, as well as diseases such as acute infections and cancer, can lead to increased breakdown of substances and increased catabolism. Poor nutrition can lead to weight loss, poor physical performance, and metabolic disorders. Amino acid mixtures are the best way to influence metabolic homeostasis, since protein synthesis occurs only from free amino acids. They are widely used in medical practice, including for parenteral nutrition. The RGNPMCG of the Ministry of Health of the Republic of Uzbekistan has developed a new blood substitute containing amino acids and an antioxidant complex, which has a wide spectrum of action and is able to influence protein synthesis by body cells, optimize the functioning of physiological systems, and accelerate recovery processes in severe diseases associated with impaired protein -energy metabolism. The purpose of this study is to study the impact and evaluate the effectiveness of a new domestic amino acid blood substitute on metabolic disorders and endogenous intoxication in toxic hepatitis.